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Sodium lauryl sulfate and recurrent aphthous ulcers. A preliminary study.

Herlofson BB, Barkvoll P.

Department of Oral Surgery and Oral Medicine, Dental Faculty, University of Oslo, Norway.

Sodium lauryl sulfate (SLS), a synthetic detergent commonly used in dentifrices, is an effective denaturant. The aim of the present study was to investigate the effect of SLS in patients with recurrent aphthous ulcers (RAU). Ten patients with multiple minor RAU participated in the study. The mean incidence of RAU was 17.8 during a 3-month period before the study. The patients used a dentifrice containing 1.2% SLS for a test period of 3 months followed by a dentifrice without SLS for the same time period. The results showed a statistically significant decrease in the number of aphthous ulcers from 14.3 after using the SLS-containing dentifrice to 5.1 ulcers after brushing with the SLS-free dentifrice (p < 0.05). It is suggested that the denaturing effect of SLS on the oral mucin layer, with exposure of the underlying epithelium, induces an increased incidence of RAU.

Publication Types:

  • Clinical Trial

  • Randomized Controlled Trial


PMID: 7825393 [PubMed - indexed for MEDLINE]

 
The effect of two toothpaste detergents on the frequency of recurrent aphthous ulcers.

Herlofson BB, Barkvoll P.

Department of Oral Surgery and Oral Medicine, Dental Faculty, University of Oslo, Norway.

The aim of the present clinical double-blind crossover study was to investigate the effect of two different toothpaste detergents, sodium lauryl sulfate (SLS) and cocoamidopropyl betaine (CAPB), as compared with a detergent-free paste, on 30 patients with frequent occurrences of recurrent aphthous ulcers. The study consisted of three 6-week periods during which the patients brushed twice daily with the different test toothpastes. The localization and number of new ulcers were assessed. A significantly higher frequency of aphthous ulcers was demonstrated when the patients brushed with an SLS- than with a CAPB-containing or a detergent-free placebo paste. An SLS-free toothpaste may thus be recommended for patients with recurrent aphthous ulcers.

Publication Types:
  • Clinical Trial

  • Randomized Controlled Trial


PMID: 8811135 [PubMed - indexed for MEDLINE]

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